General Cell Lines and Cell Cultures
Thermo Scientific™ GeneBLAzer™ NPSR1-A-NFAT-bla CHO-K1 Cells
The GeneBLAzer™ NPSR1-A-NFAT-bla CHO-K1 cells contain the human Neuropeptide S Receptor 1-Isoform A stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
Thermo Scientific™ Tango™ DRD1-bla U2OS Cells
The Tango™ DRD1-bla U2OS cells contain the human Dopamine Receptor 1 (DRD1) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.
Thermo Scientific™ GeneBLAzer™ H2-CRE-bla HEK 293T Cells
GeneBLAzer™ H2-CRE-bla HEK293T cells contain the human Histamine Receptor 2 (H2) stably integrated into the CellSensor™ CRE-bla HEK293T cell line.
Thermo Scientific™ GeneBLAzer™ D2-Gqo5-NFAT-bla CHO-K1 Cells
GeneBLAzer™ D2-Gqo5-NFAT-bla CHO-K1 cells contain the human Dopamine Receptor 2 (D2) stably integrated into the GeneBLAzer™ Gqo5-NFAT-bla CHO-K1 cell line.
Thermo Scientific™ CellSensor™ DHFR/E2F-bla NIH3T3 Cell Line
The CellSensor™ dhfr(E2F)-bla NIH 3T3 Cell Line contains a beta-lactamase reporter gene under control of the E2F/DP1 binding sequence from the DHFR gene promoter, stably integrated into NIH 3T3 cells.
Thermo Scientific™ Tango™ NPY5R-bla U2OS Cells
The Tango™ NPY5R -bla U2OS cells contain the human Neuropeptide Y Receptor Y5 (NPY5R) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.
Thermo Scientific™ LanthaScreen™ STAT3 GripTite™ Cell Line
The JAK/STAT3 signaling pathway is known to be activated by cytokines such as IL-6. In this pathway, binding of IL-6 to its cell-surface receptors results in the activation of JAKs, which in turn phosphoactivate STAT3 proteins at a specific tyrosine residue (Y705).
Thermo Scientific™ GeneBLAzer™ AVPR1a-NFAT-bla CHO-K1 Cells
GeneBLAzer™ AVPR1a-NFAT-bla CHO-K1 cells contain the human Arginine Vasopressin Receptor 1a (AVPR1a) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
Thermo Scientific™ Tango™ PTAFR-bla U2OS Cells
The Tango™ PTAFR-bla U2OS cells contain the human Platelet Activating Factor Receptor (PTAFR) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tango™ GPCR-bla U2OS parental cell line.
Thermo Scientific™ GeneBLAzer™ PPARδ-UAS-bla HEK 293T Cells
PPAR delta-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Peroxisome Proliferator-Activated Receptor-delta (PPAR delta) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzer™UAS-bla HEK 293T cell line.
Thermo Scientific™ CellSensor™ c-Fos-bla ME-180 Cell Line
The CellSensor™ c-fos-bla ME-180 cell line contains a beta-lactamase reporter gene under control of the c-fos response element stably integrated into ME-180 cells.
Thermo Scientific™ GeneBLAzer™ P2RY6-NFAT-bla CHO-K1 Cells
GeneBLAzer™ P2RY6-NFAT-bla CHO-K1 cells contain the human Purinergic receptor P2, G protein-coupled, 6 (P2RY6) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
Thermo Scientific™ CellSensor™ HRE-bla HCT-116 Cell Line
The CellSensor™ HRE-bla HCT-116 Cell Line contains a beta-lactamase reporter gene under control of the HRE stably integrated into HCT-116 cells. This cell line is validated for EC50 and Z'-factor under optimized conditions using deferoxamine (DFO) and Cobalt Chloride.
Thermo Scientific™ CellSensor™ irf1-bla CTLL-2 Cell Line
Jak/Stat signaling pathways play essential roles in the cellular responses to distinct cytokines.
Thermo Scientific™ GeneBLAzer™ NMUR1-NFAT-bla CHO-K1 Cells
GeneBLAzer™ NMUR1-NFAT-bla CHO-K1 cells contain the human Neuromedin U-25 receptor 1 (NMUR1) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.